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首发精神分裂症患者治疗前后血清脑源性神经营养因子的变化
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首发精神分裂症患者治疗前后血清脑源性神经营养因子的变化
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Journal Article
首发精神分裂症患者治疗前后血清脑源性神经营养因子的变化
2015
Overview
目的探讨精神分裂症首发未服药患者血清脑源性神经营养因子（BDNF）的特点及其与临床疗效的关系。方法研究组39例患者,符合DSM-Ⅳ中精神分裂症的诊断标准,首次发病未进行过药物治疗,均给予单一非典型抗精神病药物治疗6周,治疗前、治疗6周末完成阳性和阴性症状量表（PANSS）评估和BDNF含量测定。健康对照30例,入组时完成血清BDNF含量测定。结果研究组血清BDNF含量治疗前、后分别为（6.82±2.15）μg/L、（8.16±2.84）μg/L,治疗后高于治疗前,差异有统计学意义（t=2.349,P=0.021）,但均低于对照组的（11.6±3.32）μg/L,差异有统计学意义（t=7.239,P〈0.001;t=4.634,P〈0.001）。与治疗前比较,治疗后患者的PANSS总分、阳性症状评分、阴性症状评分及一般精神病理评分均下降,差异有统计学意义（t=6.164,P〈0.001;t=4.520,P〈0.001;t=4.132,P〈0.001;t=5.142,P〈0.001）。治疗前血清BDNF含量与PANSS总评分减分率、阴性症状评分减分率呈正相关（r=0.348、0.351,P均〈0.05）,与阳性症状分减分率、一般精神病理评分减分率及病程无相关性（r=0.204、0.186、-0.058,P均〉0.05）;治疗前后的血清BDNF含量变化值与病程呈负相关（r=-0.345,P〈0.05）,与PANSS总评分及各因子评分的减分率均无相关性（r=0.036-0.174,P〉0.05）。结论精神分裂症首发未服药患者的血清BDNF含量低于正常人,治疗后血清BDNF可提高;治疗前的含量可能作为预测药物疗效的指标之一。
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