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Tuberculous Meningitis - Adjunctive Therapy: Corticosteroids, Aspirin, or Both
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Journal Article
Tuberculous Meningitis - Adjunctive Therapy: Corticosteroids, Aspirin, or Both
2019
Overview
[2] The role of cytokines especially tumor necrosis factor, vascular endothelial growth factor, and matrix metalloproteinases in the blood–brain barrier (BBB) damage, attracting leucocytes, and release of vasoactive autocoids have been suggested. The addition of aspirin to antituberculosis drug regimen did not significantly reduce mortality [Relative risk (RR) = 0.66 (0.42–1.02); low-quality evidence] but significantly reduced the risk of new infarcts [RR = 0.52 (0.29–0.92); moderate-quality evidence]. [...]there are no high-quality data for the beneficial effects of this combination as adjunctive therapy in TBM. [...]time, all the HIV-negative patients with TBM should receive the benefit of adjunctive corticosteroid therapy.
Publisher
Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd
Subject
