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MicroRNAs： a novel promising therapeutic target for cerebral ischemia/reperfusion injury
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MicroRNAs： a novel promising therapeutic target for cerebral ischemia/reperfusion injury
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Journal Article
MicroRNAs： a novel promising therapeutic target for cerebral ischemia/reperfusion injury
2015
Overview
To determine the molecular mechanism of cerebral ischemia/reperfusion injury, we examined the micro RNA（mi RNA） expression profile in rat cortex after focal cerebral ischemia/reperfusion injury using mi RNA microarrays and bioinformatic tools to systematically analyze Gene Ontology（GO） function classifications, as well as the signaling pathways of genes targeted by these differentially expressed mi RNAs. Our results show significantly changed mi RNA expression profiles in the reperfusion period after focal cerebral ischemia, with a total of 15 mi RNAs up-regulated and 44 mi RNAs down-regulated. Target genes of these differentially expressed mi RNAs were mainly involved in metabolic and cellular processes, which were identified as hub nodes of a mi RNA-GO-network. The most correlated pathways included D-glutamine and D-glutamate metabolism, the renin-angiotensin system, peroxisomes, the PPAR signaling pathway, SNARE interactions in vesicular transport, and the calcium signaling pathway. Our study suggests that mi RNAs play an important role in the pathological process of cerebral ischemia/reperfusion injury. Understanding mi RNA expression and function may shed light on the molecular mechanism of cerebral ischemia/reperfusion injury.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Faculty of Clinical Medicine, Yunnan University of Traditional Chinese Medicine,the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China%School of Economics of Sichuan University, Chengdu, Sichuan Province, China%Department of Neurosurgery, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China%Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan Province, China,Institute of Neuroscience, Kunming Medical University, Kunming, Yunnan Province, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
