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Dopamine-Induced Recruitment of Dopamine D1 Receptors to the Plasma Membrane
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Dopamine-Induced Recruitment of Dopamine D1 Receptors to the Plasma Membrane
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Journal Article
Dopamine-Induced Recruitment of Dopamine D1 Receptors to the Plasma Membrane
1998
Overview
The recruitment of G protein-coupled receptors from the cytoplasm to the plasma membrane generally is believed to be a constitutive process. We show here by the use of both confocal microscopy and subcellular fractionation that, for at least one such receptor, this recruitment is regulated and not constitutive. Cells from a proximal tubular-like cell line, LLCPK1 cells, were incubated with either a D1 agonist, a dopamine precursor, or an inhibitor of dopamine metabolism to increase dopamine availability in the cell. Each of the three procedures led to a rapid translocation of dopamine D1 receptors from the cytosol to the plasma membrane.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences,The National Academy of Sciences
Subject
/ Cell Membrane - drug effects
/ Cells
/ Dopamine Agonists - pharmacology
/ Dopamine Antagonists - pharmacology
/ Fluorescent Antibody Technique, Direct
/ Humans
/ Kidney Tubules, Proximal - drug effects
/ Kidney Tubules, Proximal - metabolism
/ Ligands
/ Plasma
/ Proteins
