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Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study
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Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study
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Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study
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Journal Article
Staphylococcus aureus nasal carriage is associated with faster symptom resolution following nasal allergen challenge in ragweed-allergic participants: a subset of the Allergic Rhinitis Microbiome Study
2025
Overview
In this letter, we report that ragweed-allergic participants with nasal
Staphylococcus aureus
carriage (n = 7) exhibited significantly smaller reductions in Peak Nasal Inspiratory Flow from baseline at 3 h (
P
= 0.013) and 5 h (
P
= 0.008) post–nasal allergen challenge compared to non-carriers (n = 12). There was no significant difference between carriers and non-carriers in the initial response within the first three hours following the challenge (all
P
> 0.05). Carriers also reported significantly lower Total Nasal Symptom Scores (
P
= 0.015) and Total Rhinoconjunctivitis Symptom Scores (
P
= 0.021) at 48 h. These findings suggest that
S. aureus
carriage does not exacerbate allergic responses and may instead be associated with more rapid symptom resolution.
