Journal Article

Chlorhexidine Preserves Dentin Bond in vitro

PASHLEY D. H., GERALDELI S., TAY F. R., DI HIPOLITO V., TJADERHANE L., DE GOES M. F., CARRILHO M. R. O., CARVALHO R. M.

2007

Overview

Loss of hybrid layer integrity compromises resin-dentin bond stability. Matrix metalloproteinases (MMPs) may be partially responsible for hybrid layer degradation. Since chlorhexidine inhibits MMPs, we hypothesized that chlorhexidine would decelerate the loss of resin-dentin bonds. Class I preparations in extracted third molars were sectioned into two halves. One half was customarily restored (etch-and-rinse adhesive/resin composite), and the other was treated with 2% chlorhexidine after being acid-etched before restoration. Specimens were stored in artificial saliva with/without protease inhibitors. Microtensile bond strengths and failure mode distribution under SEM were analyzed immediately after specimens’ preparation and 6 months later. With chlorhexidine, significantly better preservation of bond strength was observed after 6 months; protease inhibitors in the storage medium had no effect. Failure analysis showed significantly less failure in the hybrid layer with chlorhexidine, compared with controls after 6 months. In conclusion, this in vitro study suggests that chlorhexidine might be useful for the preservation of dentin bond strength.

• Publisher: SAGE Publications,SAGE PUBLICATIONS, INC
• Subject: Acid Etching, Dental / adhesive / Anti-Infective Agents, Local - chemistry / Chlorhexidine - chemistry / Composite Resins - chemistry / Dental Bonding / Dental Cavity Preparation - classification / Dental Restoration, Permanent - methods / Dentin - ultrastructure / Dentin-Bonding Agents - chemistry / Humans / hybrid layer / matrix metalloproteinase / Microscopy, Electron, Scanning / microtensile / Protease Inhibitors - chemistry / Saliva, Artificial - chemistry / Stress, Mechanical / Surface Properties / Tensile Strength / Time Factors / tooth