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Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
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Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
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Journal Article
Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy
2020
Overview
With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.
Publisher
Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group
Subject
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Cell Proliferation - drug effects
/ Drug Screening Assays, Antitumor
/ Humans
/ PDT
/ Photosensitizing Agents - chemical synthesis
/ Photosensitizing Agents - chemistry
/ Photosensitizing Agents - pharmacology
/ Porphyrins - chemical synthesis
/ Review
