Asset Details
Do you wish to reserve the book?
Dynamic Addressing Molecular Robot (DAMR): An Effective and Efficient Trial‐and‐Error Approach for the Analysis of Single Nucleotide Polymorphisms
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Dynamic Addressing Molecular Robot (DAMR): An Effective and Efficient Trial‐and‐Error Approach for the Analysis of Single Nucleotide Polymorphisms
Do you wish to request the book?
Dynamic Addressing Molecular Robot (DAMR): An Effective and Efficient Trial‐and‐Error Approach for the Analysis of Single Nucleotide Polymorphisms
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Dynamic Addressing Molecular Robot (DAMR): An Effective and Efficient Trial‐and‐Error Approach for the Analysis of Single Nucleotide Polymorphisms
2024
Overview
Accurate and efficient molecular recognition plays a crucial role in the fields of molecular detection and diagnostics. Conventional trial‐and‐error‐based molecular recognition approaches have always been challenged in distinguishing minimal differences between targets and non‐targets, such as single nucleotide polymorphisms (SNPs) of oligonucleotides. To address these challenges, here, a novel concept of dynamic addressing analysis is proposed. In this concept, by dissecting the regions of the target and creating a corresponding recognizer, it is possible to eliminate the inaccuracy and inefficiency of recognition. To achieve this concept, a Dynamic Addressing Molecular Robot (DAMR), a DNA‐based dynamic addressing device is developed which is capable of dynamically locating targets. DAMR is designed to first bind to the conserved region of the target while addressing the specific region dynamically until accurate recognition is achieved. DAMR has provided an approach for analyzing low‐resolution targets and has been used for analyzing SNP of miR‐196a2 in both cell and serum samples, which has opened new avenues for effective and efficient molecular recognition. This work proposes a novel concept of dynamic addressing analysis by designing a Dynamic Addressing Molecular Robot to accurately and efficiently distinguish multiple targets that have minimal distinctions in complex systems. This method shows higher accuracy and efficiency compared to traditional methods, demonstrating good analysis performance in both cells and serum samples.
