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Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
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Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
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Journal Article
Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion
2021
Overview
Autophagy classically functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling via lysosomal pathways. However, accumulating evidence also supports roles for autophagy‐related genes (ATGs) in non‐degradative processes including cellular secretion. Here, we review emerging roles for the autophagy machinery in regulating extracellular vesicle loading and secretion and discuss how functional coupling of these pathways may impact normal physiology and disease.
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