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Assessment of genetic stability of Brucella melitensis Rev 1 vaccine strain by multiple-locus variable-number tandem repeat analysis
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Assessment of genetic stability of Brucella melitensis Rev 1 vaccine strain by multiple-locus variable-number tandem repeat analysis
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Journal Article
Assessment of genetic stability of Brucella melitensis Rev 1 vaccine strain by multiple-locus variable-number tandem repeat analysis
2007
Overview
The assessment of the genetic stability is one of the essential elements to guarantee the biological quality of live anti-bacteria vaccines. Live attenuated
Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants. Thirty-six
B. melitensis Rev 1 vaccine strains isolated from human or animal sources from different geographic regions, from different commercial batches or laboratory collections were typed by the multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA) recently described for
Brucella spp. Our results demonstrated that
B. melitensis Rev 1 group as assayed by MLVA is genetically very homogeneous. We believe that MLVA methodology could be an essential assay to guarantee the quality and stability of live anti-bacterial vaccines being produced worldwide and can be included as in vitro control.
Publisher
Elsevier Ltd,Elsevier
Subject
/ Animals
/ Bacterial Vaccines - genetics
/ Biochemistry, Molecular Biology
/ Biological and medical sciences
/ Brucella
/ Fundamental and applied biological sciences. Psychology
/ Genotype
/ Humans
/ MLVA
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
/ VNTR
