Asset Details
Do you wish to reserve the book?
Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
Do you wish to request the book?
Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol
2017
Overview
Previous studies have demonstrated that alcohol consumption impairs neuroplasticity in the motor cortex. However, it is unknown whether alcohol produces a similar impairment of neuroplasticity in the dorsolateral prefrontal cortex (DLPFC), a brain region that plays an important role in cognitive functioning. The aim of the current study was to evaluate the effect of alcohol intoxication on neuroplasticity in the DLPFC. Paired associative stimulation (PAS) combined with electroencephalography (EEG) was used for the induction and measurement of associative LTP-like neuroplasticity in the DLPFC. Fifteen healthy subjects were administered PAS to the DLPFC following consumption of an alcohol (1.5 g/l of body water) or placebo beverage in a within-subject cross-over design. PAS induced neuroplasticity was indexed up to 60 minutes following PAS. Additionally, the effect of alcohol on PAS-induced potentiation of theta-gamma coupling (an index associated with learning and memory) was examined prior to and following PAS. Alcohol consumption resulted in a significant impairment of mean (t = 2.456, df = 13, p = 0.029) and maximum potentiation (t = −2.945, df = 13, p = 0.011) compared to the placebo beverage in the DLPFC and globally. Alcohol also suppressed the potentiation of theta-gamma coupling by PAS. Findings from the present study provide a potential neurophysiological mechanism for impairment of cognitive functioning by alcohol.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Adult
/ Alcohol
/ Alcoholic Intoxication - etiology
/ Alcoholic Intoxication - pathology
/ Alcohols
/ Central Nervous System Depressants - adverse effects
/ EEG
/ Evoked Potentials, Motor - drug effects
/ Female
/ Humanities and Social Sciences
/ Humans
/ Learning
/ Male
/ Memory
/ Placebos
/ Prefrontal Cortex - drug effects
/ Prefrontal Cortex - pathology
/ Science
