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Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections
by
Westman, Klara
, Dahlqvist, Sofia
, Tuomilehto, Jaakko
, Lind, Marcus
, Hirsch, Irl B.
, Wijkman, Magnus O.
, Imberg, Henrik
in
Antidiabetics
/ Blood Glucose
/ Clinical Medicine
/ Diabetes
/ Diabetes Mellitus, Type 2 - drug therapy
/ Fasting
/ GLP-1 analogues
/ Glucagon
/ Glucose monitoring
/ Glycated Hemoglobin A - analysis
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Insulin
/ Insulin - therapeutic use
/ Insulin secretion
/ Klinisk medicin
/ Laboratories
/ Liraglutide - adverse effects
/ Multiple daily insulin injections
/ Peptides
/ Standard deviation
/ Type 2 diabetes mellitus
/ Values
2022
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Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections
by
Westman, Klara
, Dahlqvist, Sofia
, Tuomilehto, Jaakko
, Lind, Marcus
, Hirsch, Irl B.
, Wijkman, Magnus O.
, Imberg, Henrik
in
Antidiabetics
/ Blood Glucose
/ Clinical Medicine
/ Diabetes
/ Diabetes Mellitus, Type 2 - drug therapy
/ Fasting
/ GLP-1 analogues
/ Glucagon
/ Glucose monitoring
/ Glycated Hemoglobin A - analysis
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Insulin
/ Insulin - therapeutic use
/ Insulin secretion
/ Klinisk medicin
/ Laboratories
/ Liraglutide - adverse effects
/ Multiple daily insulin injections
/ Peptides
/ Standard deviation
/ Type 2 diabetes mellitus
/ Values
2022
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Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections
by
Westman, Klara
, Dahlqvist, Sofia
, Tuomilehto, Jaakko
, Lind, Marcus
, Hirsch, Irl B.
, Wijkman, Magnus O.
, Imberg, Henrik
in
Antidiabetics
/ Blood Glucose
/ Clinical Medicine
/ Diabetes
/ Diabetes Mellitus, Type 2 - drug therapy
/ Fasting
/ GLP-1 analogues
/ Glucagon
/ Glucose monitoring
/ Glycated Hemoglobin A - analysis
/ Humans
/ Hypoglycemic Agents - therapeutic use
/ Insulin
/ Insulin - therapeutic use
/ Insulin secretion
/ Klinisk medicin
/ Laboratories
/ Liraglutide - adverse effects
/ Multiple daily insulin injections
/ Peptides
/ Standard deviation
/ Type 2 diabetes mellitus
/ Values
2022
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Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections
Journal Article
Effect of liraglutide on markers of insulin production in persons with type 2 diabetes treated with multiple daily insulin injections
2022
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Overview
In this post-hoc analysis of data from a randomised clinical trial, we compared the effect of liraglutide to placebo on markers of insulin secretion in persons with type 2 diabetes treated with multiple daily insulin injections. Liraglutide increased insulin secretion, measured by C-peptide, by 19% after 24 weeks of treatment.
EudraCT 2012-001941-42.
•In T2D patients with MDI, liraglutide increased C-peptide compared to placebo.•Liraglutide decreased the proinsulin/C-peptide ratio compared to placebo.•Liraglutide may improve beta cell function in T2DM patients who use MDI.
Publisher
Elsevier Inc,Elsevier Limited
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