Journal Article

Multicriteria plan optimization in the hands of physicians: a pilot study in prostate cancer and brain tumors

Shih, Helen A., Müller, Birgit S., Bortfeld, Thomas, Efstathiou, Jason A., Craft, David

2017

Overview

Background The purpose of this study was to demonstrate the feasibility of physician driven planning in intensity modulated radiotherapy (IMRT) with a multicriteria optimization (MCO) treatment planning system and template based plan optimization. Exploiting the full planning potential of MCO navigation, this alternative planning approach intends to improve planning efficiency and individual plan quality. Methods Planning was retrospectively performed on 12 brain tumor and 10 post-prostatectomy prostate patients previously treated with MCO-IMRT. For each patient, physicians were provided with a template-based generated Pareto surface of optimal plans to navigate, using the beam angles from the original clinical plans. We compared physician generated plans to clinically delivered plans (created by dosimetrists) in terms of dosimetric differences, physician preferences and planning times. Results Plan qualities were similar, however physician generated and clinical plans differed in the prioritization of clinical goals. Physician derived prostate plans showed significantly better sparing of the high dose rectum and bladder regions (p(D1) < 0.05; D1: dose received by 1% of the corresponding structure). Physicians’ brain tumor plans indicated higher doses for targets and brainstem (p(D1) < 0.05). Within blinded plan comparisons physicians preferred the clinical plans more often (brain: 6:3 out of 12, prostate: 2:6 out of 10) (not statistically significant). While times of physician involvement were comparable for prostate planning, the new workflow reduced the average involved time for brain cases by 30%. Planner times were reduced for all cases. Subjective benefits, such as a better understanding of planning situations, were observed by clinicians through the insight into plan optimization and experiencing dosimetric trade-offs. Conclusions We introduce physician driven planning with MCO for brain and prostate tumors as a feasible planning workflow. The proposed approach standardizes the planning process by utilizing site specific templates and integrates physicians more tightly into treatment planning. Physicians’ navigated plan qualities were comparable to the clinical plans. Given the reduction of planning time of the planner and the equal or lower planning time of physicians, this approach has the potential to improve departmental efficiencies.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Alternative planning / Biomedical and Life Sciences / Biomedicine / Bladder / Brain / Brain cancer / Brain Neoplasms - radiotherapy / Brain stem / Brain tumors / Cancer Research / Cancer surgery / Cancer therapies / Care and treatment / Comparative analysis / Dosimetry / Efficiency / Feasibility / Feasibility studies / Health services / Humans / Imaging / IMRT / Male / Medical personnel / Multicriteria optimization / Multiple criterion / Oncology / Optimization / Optimization algorithms / Pareto optimization / Patient outcomes / Patients / Physician IMRT planning / Physicians / Pilot Projects / Planning / Practice / Prostate cancer / Prostatectomy / Prostatic Neoplasms - radiotherapy / Quality / Radiation therapy / Radiology / Radiotherapy / Radiotherapy Dosage / Radiotherapy Planning, Computer-Assisted - methods / Radiotherapy, Intensity-Modulated - methods / Rectum / Statistical analysis / Tumors / Workflow