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The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance
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The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance
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Journal Article
The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance
2018
Overview
* Letter * Open Access The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance * Cédric Carrié1, 6Email author, * Sébastien Rubin2, * Pierre Sioniac1, * Dominique Breilh3, 4 and * Matthieu Biais1, 5 Critical Care2018 22:177 https://doi.org/10.1186/s13054-018-2117-7 © The Author(s). [...]the area under the ROC curve generated for KeGFR was significantly lower than the one generated for measured CrCL for prediction of piperacillin underdosing (0.76 [0.68–0.83] vs 0.85 [0.79–0.91], p = 0.03; Fig. 2). The importance of empiric antibiotic dosing in critically ill trauma patients: are we under-dosing based on augmented renal clearance and inaccurate renal clearance estimates? J Trauma Acute Care Surg. 2016;81(6):1115–21.View ArticlePubMedGoogle Scholar Carrié C, Petit L, d'Houdain N, Sauvage N, Cottenceau V, Lafitte M, Foumenteze C, Hisz Q, Menu D, Legeron R, Breilh D, Sztark F. Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of β-lactams administered by continuous infusion: a prospective observational study.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
