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Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10

by Pardhe, Nilesh , Bajpai, Manas , Kumar, Manish

in Adenoma / Adipocytes / Admixtures / Adult / Antigens, CD34 - analysis / Bends / Buccal mucosa / Care and treatment / Case Report / Case reports / CD34 / CD34 antigen / Cell differentiation / Collagen / connective tissue tumor / Connective tissue tumors / Connective tissues / Diagnosis / Diagnosis, Differential / Genetic aspects / Health aspects / Humans / Immunohistochemistry / Lipoma / Lipoma - chemistry / Male / Mast cells / Mouth / Mouth Neoplasms - chemistry / Mouth Neoplasms - diagnosis / Mouth Neoplasms - pathology / Neurofibroma / Neurofibroma - chemistry / Neurofibroma - diagnosis / Neurofibroma - pathology / Oral cavity / soft-tissue tumor / SOX10 / Sox10 protein / SOXE Transcription Factors - analysis / spindle cell lipoma / Stroma / Tumors

2018

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Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10

by Pardhe, Nilesh , Bajpai, Manas , Kumar, Manish

2018

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Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10

by Pardhe, Nilesh , Bajpai, Manas , Kumar, Manish

2018

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Journal Article

Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10

Pardhe, Nilesh,

Bajpai, Manas,

Kumar, Manish

2018

Overview

Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lipomas, for SCL, it is an exceedingly rare location. We report a case of an asymptomatic swelling of buccal mucosa that simulated the features of neurofibroma on histopathological examination, and the final diagnosis of SCL was made on the basis of immunohistochemical features. This is the first documentation of oral SCL using SOX10 to achieve the final diagnosis.

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Publisher

Wolters Kluwer - Medknow,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Wolters Kluwer Medknow Publications

Subject

Adenoma

/ Adipocytes

/ Admixtures

/ Adult

/ Antigens, CD34 - analysis

/ Bends

/ Buccal mucosa