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Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

by Broer, Linda , Dessa Sadovnick, A , Lundström, Wangko , van Duijn, Cornelia M , Hintzen, Rogier Q , Link, Jenny , Del-Favero, Jurgen , Oostra, Ben A , Goossens, Dirk , Greiner, Eva , Hillert, Jan , Ebers, George C , Ramagopalan, Sreeram V , Aulchenko, Yurii S , Van Broeckhoven, Christine , Jafari, Naghmeh , Hoppenbrouwers, Ilse A

in Agriculture / Animal Genetics and Genomics / Biological and medical sciences / Biological variation / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Case-Control Studies / Data collection / Disease susceptibility / Family physicians / Fundamental and applied biological sciences. Psychology / Gene Function / Gene loci / Genetic aspects / Genetic diversity / Genetic Predisposition to Disease / Genetic variation / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Human Genetics / Immune response / Introns / Kinesin - genetics / Medical sciences / Multiple sclerosis / Multiple Sclerosis - genetics / Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis / Neurology / Regression analysis / Risk factors

2008

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Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

2008

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2008

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Journal Article

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Broer, Linda,

Dessa Sadovnick, A,

Lundström, Wangko,

van Duijn, Cornelia M,

Hintzen, Rogier Q,

Link, Jenny,

Del-Favero, Jurgen,

Oostra, Ben A,

Goossens, Dirk,

Greiner, Eva,

Hillert, Jan,

Ebers, George C,

Ramagopalan, Sreeram V,

Aulchenko, Yurii S,

Van Broeckhoven, Christine,

Jafari, Naghmeh,

Hoppenbrouwers, Ilse A

2008

Overview

Rogier Hintzen and colleagues report the results of a search for genetic variants associated with susceptibility to multiple sclerosis in a genetically isolated population that lead to identification of a new susceptibility locus in the region of the KIF1B gene on chromosome 1. The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 ( P = 2.5 × 10 −10 ). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Agriculture

/ Animal Genetics and Genomics

/ Biological and medical sciences

/ Biological variation

/ Biomedical and Life Sciences

/ Biomedicine

/ brief-communication