Asset Details
Do you wish to reserve the book?
The many facets of Notch ligands
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The many facets of Notch ligands
Do you wish to request the book?
The many facets of Notch ligands
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The many facets of Notch ligands
2008
Overview
The Notch signaling pathway regulates a diverse array of cell types and cellular processes and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands have been identified that may account for some of the pleiotropic nature associated with Notch signaling. This review focuses on the molecular mechanisms by which Notch ligands function as signaling agonists and antagonists, and discusses different modes of activating ligands as well as findings that support intrinsic ligand signaling activity independent of Notch. Post-translational modification, proteolytic processing, endocytosis and membrane trafficking, as well as interactions with the actin cytoskeleton may contribute to the recently appreciated multifunctionality of Notch ligands. The regulation of Notch ligand expression by other signaling pathways provides a mechanism to coordinate Notch signaling with multiple cellular and developmental cues. The association of Notch ligands with inherited human disorders and cancer highlights the importance of understanding the molecular nature and activities intrinsic to Notch ligands.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Calcium-Binding Proteins - chemistry
/ Calcium-Binding Proteins - physiology
/ Cancer
/ Cell Communication - physiology
/ Cell Differentiation - physiology
/ Cellular signal transduction
/ Embryonic Development - physiology
/ Genetic Diseases, Inborn - genetics
/ Genetic Diseases, Inborn - physiopathology
/ Intercellular Signaling Peptides and Proteins - chemistry
/ Intercellular Signaling Peptides and Proteins - physiology
/ Intracellular Signaling Peptides and Proteins
/ Ligands
/ Medicine
/ Membrane Proteins - chemistry
/ Membrane Proteins - physiology
/ Methods
/ Oncology
/ Peptide Hydrolases - physiology
/ Protein Processing, Post-Translational
/ Proteins
/ Receptors, Notch - physiology
/ review
We currently cannot retrieve any items related to this title. Kindly check back at a later time.