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Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
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Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
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Journal Article
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
2009
Overview
Staphylococcus aureus is the leading cause of bacterial infections in developed countries and produces a wide spectrum of diseases, ranging from minor skin infections to fatal necrotizing pneumonia. Although S. aureus infections were historically treatable with common antibiotics, emergence of drug-resistant organisms is now a major concern. Methicillin-resistant S. aureus (MRSA) was endemic in hospitals by the late 1960s, but it appeared rapidly and unexpectedly in communities in the 1990s and is now prevalent worldwide. This Review focuses on progress made toward understanding the success of community-associated MRSA as a human pathogen, with an emphasis on genome-wide approaches and virulence determinants.
Publisher
American Society for Clinical Investigation
Subject
/ Community-Acquired Infections - drug therapy
/ Community-Acquired Infections - epidemiology
/ Community-Acquired Infections - history
/ Community-Acquired Infections - microbiology
/ Drug resistance in microorganisms
/ Genomes
/ Genomics
/ Humans
/ Methicillin Resistance - genetics
/ Methicillin-Resistant Staphylococcus aureus - classification
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - pathogenicity
/ Review
/ Staphylococcal Infections - drug therapy
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - history
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus infections
