Asset Details
Do you wish to reserve the book?
Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study
Do you wish to request the book?
Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Characterization of bone metabolism in hungarian psoriatic arthritis patients: a case–control study
2021
Overview
Background
Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables.
Methods
Lumbar spine (L1-L4) and femoral neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed.
Results
Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.952 (0.607–1.292) g/cm
2
vs. 1.016 (0.760–1.550) g/cm
2
;
p
= 0.001) and DR total volumetric (284.3 (138.9–470.3) mg/cm
3
vs. 367.0 (287.0–412.0) mg/cm
3
;
p
< 0.001) BMD, 10 year probability for major osteoporotic (3.7% (0.7–32%) vs. 2.6% (0–17.5%);
p
= 0.003) and hip (0.4% (0–16%) vs. 0.05% (0–6.1%);
p
= 0.002) fracture and 25-hydroxyvitamin D status (47.5 (10–120) nmol/L vs. 64 (10–137;
p
< 0.001) nmol/L). As compared to areal assessment, volumetric BMD measurements identified a significantly higher number of patients with low bone mineral density (T-Score ≤ − 1.00) (34% vs. 88%,
p
< 0.001). Upon multiple linear regression analysis, disease activity score, as determined by DAS28 assessment, was an independent predictor of 10-year probability for major osteoporotic fracture (
B
(95%CI) = 1.351 (0.379–2.323);
p
= 0.007).
Conclusion
In the studied PsA cohort, disease activity was an independent predictor of 10-year probability for a major osteoporotic fracture, and complemented assessment of volumetric and areal BMD assured better efficacy at identifying those with low bone mineral density.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Age
/ Arthritis, Psoriatic - diagnostic imaging
/ Arthritis, Psoriatic - epidemiology
/ Clinical rheumatology and osteoporosis
/ Complications and side effects
/ Disease
/ FRAX
/ Hip
/ Humans
/ Medicine
/ Osteoporotic Fractures - diagnostic imaging
/ Osteoporotic Fractures - epidemiology
/ Radius
/ Software
