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Mechanisms of force generation and force transmission during interstitial leukocyte migration
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Mechanisms of force generation and force transmission during interstitial leukocyte migration
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Journal Article
Mechanisms of force generation and force transmission during interstitial leukocyte migration
2010
Overview
For innate and adaptive immune responses it is essential that inflammatory cells use quick and flexible locomotion strategies. Accordingly, most leukocytes can efficiently infiltrate and traverse almost every physiological or artificial environment. Here, we review how leukocytes might achieve this task mechanistically, and summarize recent findings on the principles of cytoskeletal force generation and transduction at the leading edge of leukocytes. We propose a model in which the cells switch between adhesion‐receptor‐mediated force transmission and locomotion modes that are based on cellular deformations, but independent of adhesion receptors. This plasticity in migration strategies allows leukocytes to adapt to the geometry and molecular composition of their environment.
How do leukocytes efficiently infiltrate and traverse almost every physiological or artificial environment? The authors propose a model where the cells flexibly switch between adhesion receptor mediated force transmission and locomotion modes based on cellular deformations but independent of adhesion receptors.
