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Serum homocysteine concentration as a marker for advanced diabetic nephropathy in a cohort of elderly patients
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Serum homocysteine concentration as a marker for advanced diabetic nephropathy in a cohort of elderly patients
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Journal Article
Serum homocysteine concentration as a marker for advanced diabetic nephropathy in a cohort of elderly patients
2023
Overview
Background
Hyperhomocysteinemia has been linked with chronic kidney disease (CKD). The present study investigated whether homocysteine (Hcy) serum levels might serve as a marker for the advancement of diabetic nephropathy (DN).
Methods
Clinical and laboratory indicators including Hcy, vitamin D (VD), urine protein, estimated glomerular filtration rate (eGFR) and the urinary protein/creatinine ratio in subjects > 65 years with DN (n = 1,845), prediabetes (n = 1,180) and in a non-diabetes (control) group (n = 28,720) were analyzed.
Results
DN patients had elevated Hcy concentrations, decreased VD and higher urinary protein levels, a reduced eGFR and a higher urinary protein/creatinine ratio compared with prediabetic and control subjects. After correcting for urinary protein quantitation, multivariate analysis revealed that both the Hcy concentration (
P
< 0.010) and urinary protein/creatinine ratio (
P
< 0.001) were risk factors, while the VD2 + VD3 serum concentration (
P
< 0.001) was a protective factor for DN. Moreover, Hcy > 12 µmol/L was a cut-off value for predicting advanced DN.
Conclusion
Hcy serum concentration is a potential marker for the advancement of CKD in DN but not prediabetes patients.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Diabetes
/ Diabetic Nephropathies - diagnosis
/ Diabetic Nephropathies - etiology
/ Epidermal growth factor receptors
/ Fasting
/ Glucose
/ Humans
/ Medicine
/ Prediabetic State - diagnosis
/ Proteins
/ Renal Insufficiency, Chronic - diagnosis
/ rology
/ Sexually transmitted diseases
/ STD
/ Urinary protein/creatinine ratio
/ Urine
