Journal Article

Expanding the role of PSMA PET in active surveillance

Nassour, Anthony-Joe, Dean, Thomas, Jain, Anika, Kim, Lawrence, Woo, Henry, Tarlinton, Lisa, Patterson, Imogen

2023

Overview

Introduction Accurate grading at the time of diagnosis is fundamental to risk stratification and treatment decision making, particularly for men being considered for Active Surveillance (AS). With the introduction of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) there has been considerable improvement in sensitivity and specificity for the detection and staging of clinically significant prostate cancer. Our study aims to determine the role of PSMA PET/CT in men with newly diagnosed low or favourable intermediate risk prostate cancer to better select men for AS. Method This is a retrospective single centre study performed from January 2019 and October 2022. This study includes men identified from electronic medical record system who had undergone a PSMA PET/CT following newly diagnosed low or favourable-intermediate risk prostate cancer. Primary outcome was to assess the change in management for men being considered for AS following PSMA PET/CT results on the basis of PSMA PET characteristics. Results In total, there were 11 of 30 men (36.67%) who were assigned management by AS and 19 of 30 men (63.33%) who had definitive treatment. 15 of the 19 men that needed treatment had concerning features on PSMA PET/CT results. Of the 15 men with concerning features on PSMA PET, 9 (60%) men were found to have adverse pathological features on final prostatectomy features. Conclusion This retrospective study suggests that PSMA PET/CT has potential to influence the management of men with newly diagnosed prostate cancer that would otherwise be appropriate for active surveillance.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Active surveillance / Biopsy / Computed tomography / Decision making / Electronic medical records / Gallium Radioisotopes / Health aspects / Humans / Internal Medicine / Magnetic resonance imaging / Male / Medical imaging / Medical records / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Men / Patients / PET imaging / Positron emission tomography / Positron Emission Tomography Computed Tomography - methods / Prostate cancer / Prostatectomy / Prostatic Neoplasms - diagnostic imaging / Prostatic Neoplasms - therapy / PSMA PET / Retrospective Studies / Robotics / Surveillance / Urology / Watchful Waiting