Asset Details
Do you wish to reserve the book?
Synthetic small regulatory RNAs in microbial metabolic engineering
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Synthetic small regulatory RNAs in microbial metabolic engineering
Do you wish to request the book?
Synthetic small regulatory RNAs in microbial metabolic engineering
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Synthetic small regulatory RNAs in microbial metabolic engineering
2021
Overview
Small regulatory RNAs (sRNAs) finely control gene expression in prokaryotes and synthetic sRNA has become a useful high-throughput approach to tackle current challenges in metabolic engineering because of its many advantages compared to conventional gene knockouts. In this review, we first focus on the modular structures of sRNAs and rational design strategies of synthetic sRNAs on the basis of their modular structures. The wide applications of synthetic sRNAs in bacterial metabolic engineering, with or without the aid of heterogeneously expressed Hfq protein, were also covered. In addition, we give attention to the improvements in implementing synthetic sRNAs, which make the synthetic sRNA strategy universally applicable in metabolic engineering and synthetic biology.Key points• Synthetic sRNAs can be rationally designed based on modular structures of natural sRNAs.• Synthetic sRNAs were widely used for metabolic engineering in various microorganisms.• Several technological improvements made the synthetic sRNA strategy more applicable.
Publisher
Springer Nature B.V
