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Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells

by Mubarak, Mohammad S. , de Sousa Soares, Larissa , Negreiros, Helber Alves , Gonçalves, Juan Carlos Ramos , Peron, Ana Paula , de Gomes Farias, Marlene , da Silva, Felipe Cavalcanti Carneiro , dos Santos, Jailson Rodrigues , Montenegro, Raquel Carvalho , de Melo Cavalcante, Ana Amélia Carvalho , de Oliveira, Victor Alves , de Sousa, Natan Antônio Batista , Islam, Muhammad Torequl , Soares, Bruno Moreira , Sharifi-Rad, Javad , Pacheco, Ana Carolina Landim , de Castro e Sousa, João Marcelo , Marques, Márcia Maria Mendes

in Allium cepa / Analysis / Artemia salina / Biomedical and Life Sciences / Biomedicine / Carcinogenesis / Cell line / Coloring matter / Dye industry / Eukaryotic Cells / Food Additives - toxicity / Humans / Monoglycerides / Mutagens - toxicity / Pharmacology/Toxicology / Saccharomyces cerevisiae / Saccharomyces cerevisiae - genetics / Tartrazine / Tartrazine - toxicity

2022

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Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells

2022

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Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells

2022

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Journal Article

Cytotoxic and mutagenic effects of the food additive tartrazine on eukaryotic cells

Mubarak, Mohammad S.,

de Sousa Soares, Larissa,

Negreiros, Helber Alves,

Gonçalves, Juan Carlos Ramos,

Peron, Ana Paula,

de Gomes Farias, Marlene,

da Silva, Felipe Cavalcanti Carneiro,

dos Santos, Jailson Rodrigues,

Montenegro, Raquel Carvalho,

de Melo Cavalcante, Ana Amélia Carvalho,

de Oliveira, Victor Alves,

de Sousa, Natan Antônio Batista,

Islam, Muhammad Torequl,

Soares, Bruno Moreira,

Sharifi-Rad, Javad,

Pacheco, Ana Carolina Landim,

de Castro e Sousa, João Marcelo,

Marques, Márcia Maria Mendes

2022

Overview

Background Among the food additives used in the food industry, food dyes are considered the most toxic. For instance, tartrazine (TRZ) is a food colorant commercially available with conflicting data regarding its cytotoxic, genotoxic, and mutagenic effects. Therefore, this study aimed to evaluate the cytotoxic and mutagenic potential of TRZ using different eukaryotic cells ( in vitro ). Methods This study employed 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), brine shrimp lethality, Allium cepa and Saccharomyces cerevisiae tests. Different concentrations of TRZ and different exposure times were used in this study. Results The results demonstrate that TRZ induced a concentration-dependent toxic effect on the test systems. It also exerted cytotoxicity in fibroblasts and human gastric cells. In addition, TRZ showed mutagenic effects on the A. cepa test system. However, its toxicogenic effects may not relate to the oxidizing activity, which was confirmed by the S. cerevisiae test model. Conclusion Taken together, TRZ exerted toxicogenic effects on the test systems. Therefore, it may be harmful to health, especially its prolonged use may trigger carcinogenesis.

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Publisher

BioMed Central,BioMed Central Ltd,BMC

Subject

Allium cepa

/ Analysis

/ Artemia salina

/ Biomedical and Life Sciences

/ Biomedicine

/ Carcinogenesis

/ Cell line