Journal Article

Inositol Phospholipid Metabolism in Arabidopsis. Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C

Pical, Christophe, Mueller-Roeber, Bernd

2002

Overview

Phosphoinositides (PIs) constitute a minor fraction of total cellular lipids in all eukaryotic cells. They fulfill many important functions through interaction with a wide range of cellular proteins. Members of distinct inositol lipid kinase families catalyze the synthesis of these phospholipids from phosphatidylinositol. The hydrolysis of PIs involves phosphatases and isoforms of PI-specific phospholipase C. Although our knowledge of the roles played by plant PIs is clearly limited at present, there is no doubt that they are involved in many physiological processes during plant growth and development. In this review, we concentrate on inositol lipid-metabolizing enzymes from the model plant Arabidopsis for which biochemical characterization data are available, namely the inositol lipid kinases and PI-specific phospholipase Cs. The biochemical properties and structure of characterized and genome-predicted isoforms are presented and compared with those of the animal enzymes to show that the plant enzymes have some features clearly unique to this kingdom.

• Publisher: American Society of Plant Biologists,American Society of Plant Physiologists,Oxford University Press
• Subject: 1-phosphatidylinositol 4-kinase / 1-Phosphatidylinositol 4-Kinase - genetics / 1-Phosphatidylinositol 4-Kinase - metabolism / Amino Acid Sequence / amino acid sequences / Animals / Arabidopsis / Arabidopsis - enzymology / Arabidopsis - genetics / Arabidopsis - metabolism / Arabidopsis thaliana / biochemical pathways / Biologi / Biological and medical sciences / Biological Sciences / Brewers yeast / Cell membranes / chemical constituents of plants / enzyme activity / Enzymes / enzymology / Fundamental and applied biological sciences. Psychology / genes / Genes. Genome / genetics / Genome Analysis / Humans / Inositols / Isoenzymes / Isoenzymes - genetics / Isoenzymes - metabolism / isozymes / lipid metabolism / Lipids / Metabolism / Molecular and cellular biology / Molecular genetics / Molecular Sequence Data / Natural Sciences / Naturvetenskap / Phosphatases / phosphatidylinositol 3-kinase / Phosphatidylinositol 3-Kinases / Phosphatidylinositol 3-Kinases - genetics / Phosphatidylinositol 3-Kinases - metabolism / Phosphatidylinositol Diacylglycerol-Lyase / Phosphatidylinositols / Phosphatidylinositols - metabolism / phospholipase C / Phosphotransferases (Alcohol Group Acceptor) / Phosphotransferases (Alcohol Group Acceptor) - genetics / Phosphotransferases (Alcohol Group Acceptor) - metabolism / Phylogeny / Plant cells / Plant physiology and development / plant proteins / Proteins / Sequence Homology, Amino Acid / Type C Phospholipases / Type C Phospholipases - genetics / Type C Phospholipases - metabolism / Yeasts / Yeasts - enzymology / Yeasts - genetics