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The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction
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The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction
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Journal Article
The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction
2016
Overview
We aim to investigate the correlations between hemodynamic parameters, penile rigidity grading, and the therapeutic effects of phosphodiesterase type 5 inhibitors using color Doppler flow imaging after intracavernosal injection in patients with erectile dysfunction. This study involved 164 patients. After intracavernosal injection with a mixture of papaverine （60 mg）, prostaglandin E1 （10 μg）, and lidocaine （2%, 0.5-1 ml）, the penile vessels were assessed using color Doppler flow imaging. Penile rigidity was classified based on the Erection Hardness Score system as Grades 4, 3, 2 or 1 （corresponding to Schramek Grades Ⅴ to Ⅱ）. Then, the patients were given oral sildenafil （50-100 mg） and scored according to the International Index of Erectile Function （IIEF-5） questionnaire. The number of patients with penile rigidities of Schramek Grades Ⅱ to Ⅴ was 14, 18, 21, and 111, respectively. The IIEF-5 score was positively correlated with the refilling index of the penile cavernosal artery （r = 0.79, P 〈 0.05）, the peak systolic velocity （r= 0.45, P〈 0.05）, and penile rigidity （r= 0.75, P〈 0.05）, and was negatively correlated with the end diastolic velocity （r = -0.74, P 〈 0.05）. For patients with erectile dysfunction, both the IIEF-5 score after sildenafil administration, which is correlated with penile rigidity, and the hemodynamic parameters detected using color Doppler flow imaging may predict the effects of phosphodiesterase type 5 inhibitor treatment and could provide a reasonable model for the targeted-treatment of erectile dysfunction.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
Subject
/ Aged
/ color Doppler flow imaging; erectile dysfunction; hemodynamic parameters; penis rigidity; sildenafil
/ Erectile Dysfunction - diagnosis
/ Erectile Dysfunction - therapy
/ Humans
/ Male
/ Original
/ Patients
/ Studies
/ Ultrasonography, Doppler, Color - methods
/ Velocity
/ 勃起功能障碍
/ 应用
/ 彩色多普勒
/ 显像
/ 疗效评价
/ 磷酸二酯酶抑制剂
/ 血流速度
/ 阴茎海绵体
