Asset Details
Do you wish to reserve the book?
Etiology and early pathogenesis of malignant testicular germ cell tumors： towards possibilities for preinvasive diagnosis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Etiology and early pathogenesis of malignant testicular germ cell tumors： towards possibilities for preinvasive diagnosis
Do you wish to request the book?
Etiology and early pathogenesis of malignant testicular germ cell tumors： towards possibilities for preinvasive diagnosis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Etiology and early pathogenesis of malignant testicular germ cell tumors： towards possibilities for preinvasive diagnosis
2015
Overview
Malignant testicular germ cell tumors （TGCT） are the most frequent cancers in Caucasian males （20-40 years） with an 70% increasing incidence the last 20 years, probably due to combined action of （epi）genetic and （micro）environmental factors. It is expected that TGCT have carcinoma in situ （CIS） as their common precursor, originating from an embryonic germ cell blocked in its maturation process. The overall cure rate of TGCT is more than 90%, however, men surviving TGCT can present long-term side effects of systemic cancer treatment. In contrast, men diagnosed and treated for CIS only continue to live without these long-term side effects. Therefore, early detection of CIS has great health benefits, which will require an informative screening method. This review described the etiology and early pathogenesis of TGCT, as well as the possibilities of early detection and future potential of screening men at risk for TGCT. For screening, a well-defined risk profile based on both genetic and environmental risk factors is needed. Since 2009, several genome wide association studies （GWAS） have been published, reporting on single-nucleotide polymorphisms （SNPs） with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF71P, HPGDS, MAD1L1, RFWD3, TEX14, and PPMIE, likely to be related to TGCT development. Prenatal, perinatal, and postnatal environmental factors also influence the onset of CIS. A noninvasive early detection method for CIS would be highly beneficial in a clinical setting, for which specific miRNA detection in semen seems to be very promising. Further research is needed to develop a well-defined TGCT risk profile, based on gene-environment interactions, combined with noninvasive detection method for CIS.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
Subject
/ Age
/ Biopsy
/ Cancer
/ Carcinoma in Situ - diagnosis
/ Carcinoma in Situ - etiology
/ Carcinoma in Situ - genetics
/ Gene-Environment Interaction
/ Genome-Wide Association Study
/ Humans
/ Male
/ Men
/ Methods
/ Neoplasms, Germ Cell and Embryonal - diagnosis
/ Neoplasms, Germ Cell and Embryonal - etiology
/ Neoplasms, Germ Cell and Embryonal - genetics
/ Polymorphism, Single Nucleotide - genetics
/ Testicular Neoplasms - diagnosis
/ Testicular Neoplasms - etiology
/ Testicular Neoplasms - genetics
/ Tumors
/ 原位
/ 早期检测
/ 病因
/ 病机
/ 睾丸生殖细胞
/ 肿瘤
/ 胚胎生殖细胞
/ 诊断
