Journal Article

Development of the Crohn's disease digestive damage score, the Lémann score

Travis, Simon, Sandborn, William J, Hommes, Daniel W, Mary, Jean-Yves, Lémann, Marc, Sands, Bruce E, D'Haens, Geert, Schoelmerich, Juergen, Colombel, Jean-Frédéric, Reinisch, Walter, Kamm, Michael A., van Assche, Gert, Schreiber, Stefan, Michetti, Pierre, Irvine, Jan E., Munkholm, Pia, Fletcher, Joel G, Oresland, Tom, Hibi, Toshifumi, Tilg, Herbert, Louis, Edouard, Pariente, Benjamin, Cosnes, Jacques, Feagan, Brian G, Loftus, Edward V, Panés, Julian, Vecchi, Maurizio, Chowers, Yehuda, Danese, Silvio, Lewin, Maïté, Peyrin-Biroulet, Laurent

2011

Overview

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure disease activity at a specific point in time. An instrument to measure cumulative structural damage to the bowel, which may predict long-term disability, is needed. The aim of this article is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take into account damage location, severity, extent, progression, and reversibility, as measured by diagnostic imaging modalities and the history of surgical resection. It should not be “diagnostic modality driven”: for each lesion and location, a modality appropriate for the anatomic site (for example: computed tomography or magnetic resonance imaging enterography, and colonoscopy) will be used. A total of 24 centers from 15 countries will be involved in a cross-sectional study, which will include up to 240 patients with stratification according to disease location and duration. At least 120 additional patients will be included in the study to validate the score. The Lémann score is expected to be able to portray a patient's disease course on a double-axis graph, with time as the x-axis, bowel damage severity as the y-axis, and the slope of the line connecting data points as a measure of disease progression. This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage. (Inflamm Bowel Dis 2011)

• Publisher: Oxford University Press,Wiley Subscription Services, Inc., A Wiley Company,Lippincott, Williams & Wilkins,Lippincott Williams & Wilkins
• Subject: Chemical Sciences / Clincal Review / Colon / Colon - diagnostic imaging / Colon - pathology / Colon/pathology/radiography/ultrasonography / Colonoscopy / Computed tomography / Crohn Disease - diagnostic imaging / Crohn Disease - pathology / Crohn Disease/pathology/radiography/ultrasonography / Crohn's disease / Data processing / Disease Progression / Gastroenterology & hepatology / Gastroentérologie & hépatologie / Human health sciences / Humans / illness index severity / Inflammatory bowel diseases / Intestine / Magnetic Resonance Imaging / Organic chemistry / Sciences de la santé humaine / Severity of Illness Index / Tomography, X-Ray Computed / Ultrasonography