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Bacterial pore-forming toxins: The (w)hole story
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Journal Article
Bacterial pore-forming toxins: The (w)hole story
2008
Overview
Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat. Recent studies reveal that cells do not just swell and lyse, but are able to sense and react to pore formation, mount a defense, even repair the damaged membrane and thus survive. These responses involve a variety of signal-transduction pathways and sophisticated cellular mechanisms such as the pathway regulating lipid metabolism. In this review we discuss the different classes of bacterial PFTs and their modes of action, and provide examples of how the different bacteria use PFTs. Finally, we address the more recent field dealing with the eukaryotic cell response to PFT-induced damage.
Publisher
Basel : SP Birkhäuser Verlag Basel,SP Birkhäuser Verlag Basel,Springer Nature B.V
Subject
/ Antigens, Bacterial - chemistry
/ Antigens, Bacterial - metabolism
/ Bacteria
/ Bacterial Toxins - chemistry
/ Bacterial Toxins - metabolism
/ Biomedical and Life Sciences
/ Damage
/ Lipids
/ p38 Mitogen-Activated Protein Kinases - metabolism
/ Pore Forming Cytotoxic Proteins - classification
/ Pore Forming Cytotoxic Proteins - metabolism
/ Protein Subunits - classification
/ Protein Subunits - metabolism
/ Proteins
/ Review
/ Signal Transduction - physiology
/ Toxins
/ Virology
