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Compartmentalized signaling of Ras in fission yeast
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Compartmentalized signaling of Ras in fission yeast
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Journal Article
Compartmentalized signaling of Ras in fission yeast
2006
Overview
Compartment-specific Ras signaling is an emerging paradigm that may explain the multiplex outputs from a single GTPase. The fission yeast, Schizosaccharomyces pombe, affords a simple system in which to study Ras signaling because it has a single Ras protein, Ras1, that regulates two distinct pathways: one that controls mating through a Byr2-mitogen-activated protein kinase cascade and one that signals through Scd1-Cdc42 to maintain elongated cell morphology. We generated Ras1 mutants that are restricted to either the endomembrane or the plasma membrane. Protein binding studies showed that each could interact with the effectors of both pathways. However, when examined in ras1 null cells, endomembrane-restricted Ras1 supported morphology but not mating, and, conversely, plasma membrane-restricted Rasl supported mating but did not signal to Scd1-Cdc42. These observations provide a striking demonstration of compartment-specific Ras signaling and indicate that spatial specificity in the Ras pathway is evolutionarily conserved.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Cancer
/ Cells
/ Genes
/ Genomics
/ Guanine Nucleotide Exchange Factors - genetics
/ Guanine Nucleotide Exchange Factors - metabolism
/ MAP Kinase Kinase Kinases - genetics
/ MAP Kinase Kinase Kinases - metabolism
/ P branes
/ protein-protein interactions
/ Proteins
/ Recombinant Fusion Proteins - genetics
/ Recombinant Fusion Proteins - metabolism
/ Schizosaccharomyces - cytology
/ Schizosaccharomyces - metabolism
/ Schizosaccharomyces pombe Proteins - genetics
/ Schizosaccharomyces pombe Proteins - metabolism
/ Signal Transduction - physiology
/ Subcellular Fractions - metabolism
/ Two-Hybrid System Techniques
/ Yeasts
