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Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
by Qian, Haiyan , Xiong, Changming , Wei, Zhiyao , Yang, Yicheng
in Aldosterone / Angiotensin / Biomedical and Life Sciences / Biomedicine / Cardiomyocytes / Cardiomyopathy / Cardiovascular disease / Coronary artery disease / Coronaviruses / Coronaviruses: emerging and re-emerging pathogens in humans and animals / COVID-19 / COVID-19 infection / disease severity / Emerging viruses / Heart diseases / Medical research / Medicine, Experimental / Mortality / Muscle contraction / Myocardial injury / Renin / Review / Risk factors / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Virology
2022
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Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
by Qian, Haiyan , Xiong, Changming , Wei, Zhiyao , Yang, Yicheng
in Aldosterone / Angiotensin / Biomedical and Life Sciences / Biomedicine / Cardiomyocytes / Cardiomyopathy / Cardiovascular disease / Coronary artery disease / Coronaviruses / Coronaviruses: emerging and re-emerging pathogens in humans and animals / COVID-19 / COVID-19 infection / disease severity / Emerging viruses / Heart diseases / Medical research / Medicine, Experimental / Mortality / Muscle contraction / Myocardial injury / Renin / Review / Risk factors / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Virology
2022
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Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
by Qian, Haiyan , Xiong, Changming , Wei, Zhiyao , Yang, Yicheng
in Aldosterone / Angiotensin / Biomedical and Life Sciences / Biomedicine / Cardiomyocytes / Cardiomyopathy / Cardiovascular disease / Coronary artery disease / Coronaviruses / Coronaviruses: emerging and re-emerging pathogens in humans and animals / COVID-19 / COVID-19 infection / disease severity / Emerging viruses / Heart diseases / Medical research / Medicine, Experimental / Mortality / Muscle contraction / Myocardial injury / Renin / Review / Risk factors / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Virology
2022

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Mohammed Bin Rashid Library /
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Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update
Journal Article

Direct mechanisms of SARS-CoV-2-induced cardiomyocyte damage: an update

Qian, Haiyan,
Xiong, Changming,
Wei, Zhiyao,
Yang, Yicheng
2022
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Overview
Myocardial injury induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reportedly related to disease severity and mortality, attracting attention to exploring relevant pathogenic mechanisms. Limited by insufficient evidence, myocardial injury caused by direct viral invasion of cardiomyocytes (CMs) is not fully understood. Based on recent studies, endosomal dependence can compensate for S protein priming to mediate SARS-CoV-2 infection of CMs, damage the contractile function of CMs, trigger electrical dysfunction, and tip the balance of the renin–angiotensin–aldosterone system to exert a myocardial injury effect. In this review, we shed light on the direct injury caused by SARS-CoV-2 to provide a comprehensive understanding of the cardiac manifestations of coronavirus disease 2019 (COVID-19).
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Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject

Aldosterone

/ Angiotensin

/ Biomedical and Life Sciences

/ Biomedicine

/ Cardiomyocytes

/ Cardiomyopathy

/ Cardiovascular disease

/ Coronary artery disease

/ Coronaviruses

/ Coronaviruses: emerging and re-emerging pathogens in humans and animals

/ COVID-19

/ COVID-19 infection

/ disease severity

/ Emerging viruses

/ Heart diseases

/ Medical research

/ Medicine, Experimental

/ Mortality

/ Muscle contraction

/ Myocardial injury

/ Renin

/ Review

/ Risk factors

/ SARS-CoV-2

/ Severe acute respiratory syndrome coronavirus 2

/ Virology

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