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Primary sclerosing cholangitis
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Journal Article
Primary sclerosing cholangitis
2013
Overview
Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory bowel disease and is generally chronic and progressive. Patients frequently present with asymptomatic, anicteric cholestasis, but many develop progressive biliary strictures with time, leading to recurrent cholangitis, biliary cirrhosis, and end-stage liver disease. Medical treatment does not slow the progression of disease, and many patients need liver transplantation, after which recurrent disease is a risk. The increased incidence of hepatobiliary cancer, which is not related to the underlying severity of biliary fibrosis, is of particular concern. Risk of colorectal cancer is also increased in patients with coexistent inflammatory bowel disease. Mechanistic insights have arisen from studies of secondary sclerosing cholangitis, in which a similar clinical profile is associated with a specific cause, and genomic studies have elucidated potential disease-initiating pathways in the primary form. The close association between inflammatory bowel disease and primary sclerosing cholangitis underscores the need to further understand the role of environmental factors in generation of lymphocytes that are postulated to be retargeted, deleteriously, to the biliary tree. Treatment of primary sclerosing cholangitis is confined to supportive measures, but advances in pathobiology suggest that new stratified approaches will soon be available.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Bile
/ Bile Acids and Salts - metabolism
/ Biological and medical sciences
/ Cholangitis, Sclerosing - etiology
/ Cholangitis, Sclerosing - genetics
/ Cholangitis, Sclerosing - immunology
/ Cholangitis, Sclerosing - pathology
/ Cholangitis, Sclerosing - therapy
/ fibrosis
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Genetic Predisposition to Disease - genetics
/ genomics
/ Humans
/ Liver. Biliary tract. Portal circulation. Exocrine pancreas
/ patients
/ risk
/ Rodents
