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Lorcaserin Safety in Overweight or Obese Patients

by Scirica, Benjamin M , Zipursky, Jonathan S , Goadsby, Peter J , Vandenbussche, Nicolas , Ham, Soo-Youn , Shin, Sang W , Haghbayan, Hourmazd , Wiviott, Stephen D , Coomes, Eric A , Bohula, Erin A

in Benzazepines / Body weight / Chlorophenylpiperazine / Clinical trials / Fees & charges / Headache / Headaches / Humans / Migraine / Obesity / Overweight / Phenotypes / Serotonin S2 receptors / Side effects

2019

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Lorcaserin Safety in Overweight or Obese Patients

by Scirica, Benjamin M , Zipursky, Jonathan S , Goadsby, Peter J , Vandenbussche, Nicolas , Ham, Soo-Youn , Shin, Sang W , Haghbayan, Hourmazd , Wiviott, Stephen D , Coomes, Eric A , Bohula, Erin A

2019

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Lorcaserin Safety in Overweight or Obese Patients

by Scirica, Benjamin M , Zipursky, Jonathan S , Goadsby, Peter J , Vandenbussche, Nicolas , Ham, Soo-Youn , Shin, Sang W , Haghbayan, Hourmazd , Wiviott, Stephen D , Coomes, Eric A , Bohula, Erin A

2019

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Journal Article

Lorcaserin Safety in Overweight or Obese Patients

Scirica, Benjamin M,

Zipursky, Jonathan S,

Goadsby, Peter J,

Vandenbussche, Nicolas,

Ham, Soo-Youn,

Shin, Sang W,

Haghbayan, Hourmazd,

Wiviott, Stephen D,

Coomes, Eric A,

Bohula, Erin A

2019

Overview

To the Editor: The article by Bohula et al. (Sept. 20 issue) 1 examined the use of lorcaserin, a selective agonist of the 5-hydroxytryptamine 2C serotonin receptor (5-HT2C), in overweight or obese patients. In this trial and previous trials, 2 headache was one of the most common side effects of lorcaserin and a common reason for discontinuation. Meta-chlorophenylpiperazine (mCPP), another 5-HT2C receptor agonist and a major metabolite of trazodone, has been shown to trigger headache with migrainous phenotype among susceptible persons. 3-5 The pharmacology of lorcaserin, with its side effect of headache, reinforces the role of serotonergic mechanisms, specifically the 5-HT2C receptor, in . . .

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Publisher

Massachusetts Medical Society

Subject

Benzazepines

/ Body weight

/ Chlorophenylpiperazine