Journal Article

An agent-based model to simulate the transmission dynamics of bloodborne pathogens within hospitals

Temime, Laura, El-Kassas, Mohamed, Anwar, Wagida, Henriot, Paul, Girgis, Samia A., El Gaafary, Maha, Jean, Kévin

2025

Overview

Mathematical models are powerful tools to analyze pathogen spread and assess control strategies in healthcare settings. Nevertheless, available models focus on nosocomial transmission through direct contact or aerosols rather than through blood, even though bloodborne pathogens remain a significant source of iatrogenic infectious risk. Herein, we propose an agent-based SEI (Susceptible-Exposed-Infected) model to reproduce the transmission of bloodborne pathogens dynamically within hospitals. This model simulates the dynamics of patients between hospital wards, from admission to discharge, as well as the dynamics of the devices used during at-risk invasive procedures, considering that patient contamination occurs after exposure to a contaminated device. We first illustrate the use of this model through a case study on hepatitis C virus (HCV) in Egypt. Model parameters, such as HCV upon-admission prevalence and transition probabilities between wards or ward-specific probabilities of undergoing different invasive procedures, are informed with data collected in Ain Shams University Hospital in Cairo. Our results suggest a low risk of HCV acquisition for patients hospitalized in this university hospital. However, we show that in a low-resource hospital, frequent device shortages could lead to increased risk. We also find that systematically screening patients in a few selected high-risk wards could significantly reduce this risk. We then further explore potential model applications through a second illustrative case study based on HBV nosocomial transmission in Ethiopia. In the future, this model could be used to predict the potential burden of emerging bloodborne pathogens and help implement effective control strategies in various hospital contexts.

• Publisher: Public Library of Science,PLOS,Public Library of Science (PLoS)
• Subject: Agent based models / Analysis / Biology and Life Sciences / Blood-borne diseases / Blood-Borne Infections - epidemiology / Blood-Borne Infections - transmission / Blood-Borne Pathogens / Case studies / Computational Biology / Computer Science / Computer Simulation / Cross Infection - epidemiology / Cross Infection - transmission / Disease transmission / Diseases / Distribution / Egypt / Egypt - epidemiology / Engineering and Technology / Ethiopia / Hepacivirus / Hepatitis B / Hepatitis C / Hepatitis C - epidemiology / Hepatitis C - transmission / Hepatitis C virus / Hospital patients / Hospitals / Humans / Life Sciences / Medicine and Health Sciences / Modeling and Simulation / Models, Biological / Pathogenic microorganisms / Risk factors / Santé publique et épidémiologie