Asset Details
Do you wish to reserve the book?
Evolution and functional cross‐talk of protein post‐translational modifications
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Evolution and functional cross‐talk of protein post‐translational modifications
Do you wish to request the book?
Evolution and functional cross‐talk of protein post‐translational modifications
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Evolution and functional cross‐talk of protein post‐translational modifications
2013
Overview
Protein post‐translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post‐translational regulation and progress made in the large‐scale functional characterization of PTM function.
Graphical Abstract
Advances in proteomics have opened new avenues for the analysis of the evolution of protein post‐translational modifications (PTMs) and have enabled the large‐scale functional characterization of a range of different modifications types.
Publisher
Nature Publishing Group UK,EMBO Press,European Molecular Biology Organization,Springer Nature
Subject
We currently cannot retrieve any items related to this title. Kindly check back at a later time.