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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
by
Lavandero, Sergio
, Diaz-Vegas, Alexis
, Krycer, James R
, Morales, Pablo E
, Rothermel, Beverly A
, Sanchez-Aguilera, Pablo
, Cifuentes, Mariana
, Monsalves-Alvarez, Matías
in
Cardiovascular diseases
/ Chronic diseases
/ Chronic illnesses
/ Damage
/ Diabetes mellitus (non-insulin dependent)
/ Drug development
/ Homeostasis
/ Insulin
/ Insulin resistance
/ Metabolic disorders
/ Mitochondria
/ Reviews
/ State-of-the-art reviews
/ Type 2 diabetes
2020
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
by
Lavandero, Sergio
, Diaz-Vegas, Alexis
, Krycer, James R
, Morales, Pablo E
, Rothermel, Beverly A
, Sanchez-Aguilera, Pablo
, Cifuentes, Mariana
, Monsalves-Alvarez, Matías
in
Cardiovascular diseases
/ Chronic diseases
/ Chronic illnesses
/ Damage
/ Diabetes mellitus (non-insulin dependent)
/ Drug development
/ Homeostasis
/ Insulin
/ Insulin resistance
/ Metabolic disorders
/ Mitochondria
/ Reviews
/ State-of-the-art reviews
/ Type 2 diabetes
2020
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
by
Lavandero, Sergio
, Diaz-Vegas, Alexis
, Krycer, James R
, Morales, Pablo E
, Rothermel, Beverly A
, Sanchez-Aguilera, Pablo
, Cifuentes, Mariana
, Monsalves-Alvarez, Matías
in
Cardiovascular diseases
/ Chronic diseases
/ Chronic illnesses
/ Damage
/ Diabetes mellitus (non-insulin dependent)
/ Drug development
/ Homeostasis
/ Insulin
/ Insulin resistance
/ Metabolic disorders
/ Mitochondria
/ Reviews
/ State-of-the-art reviews
/ Type 2 diabetes
2020
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
Journal Article
Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
2020
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Overview
Abstract
Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss the role of mitochondria in maintaining cellular and whole-organism homeostasis, the mechanisms that promote mitochondrial dysfunction, and the role of this phenomenon in noncommunicable chronic diseases. We also review the state of the art regarding the preclinical evidence associated with the regulation of mitochondrial function and the development of current mitochondria-targeted therapeutics to treat noncommunicable chronic diseases. Finally, we give an integrated vision of how mitochondrial damage is implicated in these metabolic diseases.
Graphical Abstract
Graphical Abstract
Publisher
Oxford University Press,Copyright Oxford University Press
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