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A novel partial volume correction method for accurate quantification of 18F flortaucipir in the hippocampus
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A novel partial volume correction method for accurate quantification of 18F flortaucipir in the hippocampus
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A novel partial volume correction method for accurate quantification of 18F flortaucipir in the hippocampus
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Journal Article
A novel partial volume correction method for accurate quantification of 18F flortaucipir in the hippocampus
2018
Overview
BackgroundOff-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC).MethodsPVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used.ResultsFor controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05).ConclusionPVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.
Publisher
Springer Nature B.V
Subject
