Journal Article

Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

Peccin, Pâmela, Proença, Isabel, Dani, Caroline, Striebel, Vera, Marinho, Jessica, Nique, Simone, Pochmann, Daniela, Elsner, Viviane, da Silva, Ivy

2020

Overview

Parkinson's disease is a neurodegenerative disease. Oxidative stress, i.e., the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body, plays an important role in the pathogenesis of this disease. Physical exercise can regulate oxidative stress. The purpose of this study was to analyze the short- and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease. The aquatic exercise program was carried out during 1 month with two sessions per week (1 hour/session). Blood samples were collected at four different time points: pre-intervention, immediately, 48 hours, and 30 days after the first session of aquatic exercise program. Our results revealed that water-based programs modulated antioxidant enzyme activity, increased superoxide dismutase activity, reduced catalase activity, and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease. Compared with pre-intervention and 48 hours after the first session of aquatic exercise program, superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session. Our results demonstrated that aquatic exercise program could modulate oxidative stress, mainly by the effect of antioxidant enzyme activity. These results could better help understand the target of oxidative stress in Parkinson's disease. This study was approved by the Ethics Committee of Centro Universitário Metodista IPA (approval No. 1.373.911) on August 9, 2019 and registered with REBEC (registration number: RBR-6NJ4MK).

• Publisher: Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Curso de Fisioterapia do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brazil,Programa de Pós Gradua??o em Biociências e Reabilita??o do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brazil,Programa de Pós Gradua??o em Farmacologia e Terapêutica,Universidade Federal do Rio Grande do Sul,Porto Alegre,RS,Brazil%Programa de Pós Gradua??o em Biociências e Reabilita??o do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brazil%Curso de Fisioterapia do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brazil%Programa de Pós Gradua??o em Biociências e Reabilita??o do Centro Universitário Metodista-IPA,Porto Alegre,RS,Brazil,Programa de Pós Gradua??o em Ciências Biológicas: Fisiologia,Universidade Federal do Rio Grande do Sul,Porto Alegre,RS,Brazil,Wolters Kluwer - Medknow,Wolters Kluwer Medknow Publications
• Subject: antioxidant enzyme; antioxidants; aquatic exercise; exercise therapies; neurodegenerative disease; oxidative stress; parkinson’s disease / Antioxidants / Antioxidants (Nutrients) / Aquatic exercises / Care and treatment / Development and progression / Diseases / Dopamine / Exercise / Health aspects / Lipid peroxidation / Medical schools / Older people / Oxidation / Oxidative stress / Parkinson disease / Parkinson's disease / Physical fitness / Physical therapy / Reactive oxygen species / Studies