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Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

by Cai, Xiaoli , Wang, Jinlin , Lan, Yun , Gao, Ming , He, Ruiying , Tang, Yangbo , Zhao, Lingzhai , Li, Yueping , Deng, Xizi , Li, Feng , Hu, Fengyu , Fan, Qinghong , Tang, Guofang , Li, Liya , Tang, Xiaoping , Chen, Weilie , Tan, Yizhou , Deng, Xilong , Tong, Yuwei , Wen, Chunyan , Yuan, Xiaozhen

in 2019-ncov / anal swab / Betacoronavirus - genetics / Betacoronavirus - isolation & purification / blood viral RNA / Clinical Laboratory Techniques / Coronavirus Infections - blood / Coronavirus Infections - diagnosis / Coronavirus Infections - virology / Coronaviruses / COVID-19 / COVID-19 Testing / Humans / laboratory test / Letter / pharyngeal swab / Pneumonia, Viral / Real-Time Polymerase Chain Reaction / Retrospective Studies / RNA, Viral - blood / RNA, Viral - genetics / SARS-CoV-2 / Severity of Illness Index

2020

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2020

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Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

2020

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Journal Article

Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity

Cai, Xiaoli,

Wang, Jinlin,

Lan, Yun,

Gao, Ming,

He, Ruiying,

Tang, Yangbo,

Zhao, Lingzhai,

Li, Yueping,

Deng, Xizi,

Li, Feng,

Hu, Fengyu,

Fan, Qinghong,

Tang, Guofang,

Li, Liya,

Tang, Xiaoping,

Chen, Weilie,

Tan, Yizhou,

Deng, Xilong,

Tong, Yuwei,

Wen, Chunyan,

Yuan, Xiaozhen

2020

Overview

The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.

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Publisher

Taylor & Francis,Taylor & Francis Ltd,Taylor & Francis Group

Subject

2019-ncov

/ anal swab

/ Betacoronavirus - genetics

/ Betacoronavirus - isolation & purification

/ blood viral RNA

/ Clinical Laboratory Techniques

/ Coronavirus Infections - blood