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Cryptococcal meningitis: A neglected NTD?

by Mapoure, Yacouba N. , Burry, Jessica , Stone, Neil R. H. , Boulware, David R. , Greene, Gregory S. , Molloy, Síle F. , Temfack, Elvis , Lesikari, Sokoine , Dromer, Francoise , Chiller, Tom , Kanyama, Cecilia , Bicanic, Tihana , Sini, Victor , Lortholary, Olivier , Govender, Nelesh P. , Mfinanga, Sayoki , Day, Jeremy , Jaffar, Shabbar , Denning, David W. , Kouanfack, Charles , Jarvis, Joseph N. , Harrison, Thomas S. , Loyse, Angela

in Antifungal Agents - therapeutic use / Biology and Life Sciences / Biomedical Research / Cryptococcal meningitis / Diagnosis / Diseases / Global Health / Health aspects / HIV patients / HIV tests / Human health and pathology / Humans / Infectious diseases / Life Sciences / Medicine and Health Sciences / Meningitis / Meningitis, Cryptococcal - epidemiology / Meningitis, Cryptococcal - prevention & control / Mortality / Neglected Diseases / People and Places / Public health / Tropical diseases / Tropical Medicine / Viewpoints

2017

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2017

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2017

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Journal Article

Cryptococcal meningitis: A neglected NTD?

Mapoure, Yacouba N.,

Burry, Jessica,

Stone, Neil R. H.,

Boulware, David R.,

Greene, Gregory S.,

Molloy, Síle F.,

Temfack, Elvis,

Lesikari, Sokoine,

Dromer, Francoise,

Chiller, Tom,

Kanyama, Cecilia,

Bicanic, Tihana,

Sini, Victor,

Lortholary, Olivier,

Govender, Nelesh P.,

Mfinanga, Sayoki,

Day, Jeremy,

Jaffar, Shabbar,

Denning, David W.,

Kouanfack, Charles,

Jarvis, Joseph N.,

Harrison, Thomas S.,

Loyse, Angela

2017

Overview

Although HIV/AIDS has been anything but neglected over the last decade, opportunistic infections (OIs) are increasingly overlooked as large-scale donors shift their focus from acute care to prevention and earlier antiretroviral treatment (ART) initiation. Of these OIs, cryptococcal meningitis, a deadly invasive fungal infection, continues to affect hundreds of thousands of HIV patients with advanced disease each year and is responsible for an estimated 15%–20% of all AIDS-related deaths [1, 2]. Yet cryptococcal meningitis ranks amongst the most poorly funded “neglected” diseases in the world, receiving 0.2% of available relevant research and development (R&D) funding, according to Policy Cures’ 2016 Global Funding of Innovation for Neglected Diseases (G-Finder) Report [3, 4].

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Antifungal Agents - therapeutic use

/ Biology and Life Sciences

/ Biomedical Research

/ Cryptococcal meningitis

/ Diagnosis

/ Diseases

/ Global Health