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Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
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Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
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Journal Article
Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
2013
Overview
Michalina Gora and her colleagues have developed a tethered capsule endoscope in the form of a swallowable pill that does not require sedation and is the size of a one-cent coin. Once swallowed, the device was well tolerated and used to capture three-dimensional microstructural images of the digestive tract, particularly the esophagus, using optical frequency domain imaging. Feasibility was demonstrated in patients with Barrett’s esophagus, including high-grade dysplasia.
Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
Publisher
Nature Publishing Group US,Nature Publishing Group
