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Norepinephrine exposure and acute kidney injury after cardiac surgery under cardiopulmonary bypass: A post-hoc cardiox trial analysis
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Norepinephrine exposure and acute kidney injury after cardiac surgery under cardiopulmonary bypass: A post-hoc cardiox trial analysis
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Norepinephrine exposure and acute kidney injury after cardiac surgery under cardiopulmonary bypass: A post-hoc cardiox trial analysis
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Journal Article
Norepinephrine exposure and acute kidney injury after cardiac surgery under cardiopulmonary bypass: A post-hoc cardiox trial analysis
2022
Overview
[...]the prevention of renal function deterioration in the early postoperative period is important [11,12]. [...]a high dose of norepinephrine, can negatively affect renal function [14,15]. Variables AKI – (n = 265) AKI + (n = 65) p value Bonferroni Baseline characteristics Age (years) 68.0 [61.0–73.0] 67.0 [63.0–74.0] 0.298 1 Male gender (n, %) 198 (74.7) 51 (78) 0.530 1 BMI (kg.m−2) 27.0 [23.9–30.9] 28.9 [25.2–31.2] 0.291 1 Chronic Kidney disease 17 (6.6) 13 (20.0) 0.002 0.040 Diabetes 65 (25.2) 21 (32.3) 0.247 1 Hypertension 150 (58.1) 39 (60.0) 0.786 1 Acute coronary syndrome 54 (20.9) 19 (29.2) 0.155 1 Stroke 19 (7.4) 3 (4.6) 0.436 1 LVEF (%) 60.0 [53.0–66.3] 60.0 [54.5–69.0] 0.753 1 Surgery type (n, %) 0.681 1 Ascending Aorta 3 (1.2) 0 (0.0) – Combined surgery (CABG and valve) 29 (11.4) 10 (15.4) – Isolated CABG 77 (30.2) 14 (21.5) – Valve replacement 7 (2.7) 2 (3.1) – Euroscore II 3.47 [2.0, 7.2] 4.1 [2.7–9.5] 0.071 1 Intraoperative characteristics Duration of CPB (min) 93.0 [68.7–122.0] 104.0 [60.5–141.5] 0.040 1 Duration of aortic clamp (min) 69.0 [50.0–91.0] 66.0 [44.5–96.0] 0.213 1 Scv02 (%) 78.8 [73.4–83.5] 78.7 [74.2–84.9] 0.770 1 CPB blood flow (ml/min) 5025.3 [4476.0–5360.0] 5092.2 [4619.1–5514.3] 0.431 1 Mean arterial pressure (mmHg) 68.6 [62.7–73.0] 65.7 [60.9–73.4] 0.306 1 Intraoperative hemoglobin level (g.dl−1) 9.9 [8.9–10.9] 9.5 [8.5–10.9] 0.599 1 RBC transfusion (n, %) 29 (11.4) 16 (24.6) 0.007 0.140 Norepinephrine infusion Cumulative norepinephrine dose (mg) 0.00 [0.0–0.5] 1.05 [0.0–7.3] <0.005 0.006 Number of patients receiving norepinephrine (n(%)).
Publisher
Elsevier Inc,Elsevier BV,Elsevier Limited,Elsevier
