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GABA and glutamate neurons in the VTA regulate sleep and wakefulness

by Yang, Qianzi , Wang, Dan , Ma, Ying , Wisden, William , Yu, Xiao , Li, Wen , Harding, Edward C , Long, Li , Li, Yuqi , Franks, Nicholas P , Chen, Ming , Harris, Julia J , Ba, Wei , Tossell, Kyoko , Yustos, Raquel , Burdakov, Denis , Vyssotski, Alexei L , Dong, Hailong , Miracca, Giulia , Guo, Juan

in Arousal / Hypothalamus / Hypothalamus (lateral) / Neurons / Neurotransmitters / Nucleus accumbens / Sleep / Sleep and wakefulness / Wakefulness / γ-Aminobutyric acid

2019

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GABA and glutamate neurons in the VTA regulate sleep and wakefulness

in Arousal / Hypothalamus / Hypothalamus (lateral) / Neurons / Neurotransmitters / Nucleus accumbens / Sleep / Sleep and wakefulness / Wakefulness / γ-Aminobutyric acid

2019

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GABA and glutamate neurons in the VTA regulate sleep and wakefulness

in Arousal / Hypothalamus / Hypothalamus (lateral) / Neurons / Neurotransmitters / Nucleus accumbens / Sleep / Sleep and wakefulness / Wakefulness / γ-Aminobutyric acid

2019

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Journal Article

GABA and glutamate neurons in the VTA regulate sleep and wakefulness

Yang, Qianzi,

Wang, Dan,

Ma, Ying,

Wisden, William,

Yu, Xiao,

Li, Wen,

Harding, Edward C,

Long, Li,

Li, Yuqi,

Franks, Nicholas P,

Chen, Ming,

Harris, Julia J,

Ba, Wei,

Tossell, Kyoko,

Yustos, Raquel,

Burdakov, Denis,

Vyssotski, Alexei L,

Dong, Hailong,

Miracca, Giulia,

Guo, Juan

2019

Overview

Yu, Li et al. show that VTA GABA and glutamate neurons induce sleep and waking, respectively, via projections to the lateral hypothalamus and nucleus accumbens. Thus, in addition to influencing reward-directed behaviors, the VTA regulates arousal.

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Publisher

Nature Publishing Group

Subject

Arousal

/ Hypothalamus

/ Hypothalamus (lateral)

/ Neurons

/ Neurotransmitters

/ Nucleus accumbens

/ Sleep