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The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
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The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
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The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
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Journal Article
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
2014
Overview
The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
/ Biomedical and Life Sciences
/ Disease
/ Genes
/ Humans
/ Immunobiology and immunotherapy
/ Inflammatory Bowel Diseases - etiology
/ Inflammatory Bowel Diseases - metabolism
/ Ligands
/ Proteins
/ Receptors, Immunologic - chemistry
/ Receptors, Immunologic - genetics
/ Receptors, Immunologic - metabolism
/ Review
/ Rodents
