Journal Article

Are bacterial coinfections really rare in COVID-19 intensive care units?

Karaca, Banu, Tuzen, Ahmet Salih, Sencan, Atilla, Demirdal, Tuna, Girgin, Senem, Karahan, Nagihan Altıncı, Aksun, Murat, Ormen, Bahar

2023

Overview

Objectives There are limited data about nosocomial coinfections of COVID-19 cases monitored in the intensive care unit. This study aims to investigate coinfections in COVID-19 patients followed in an intensive care unit of a university hospital. Methods This study analyzed retrospectively the data of coinfections of 351 COVID-19 patients in the period 28.02.2020–15.01.2021 in a tertiary care intensive care unit in a university hospital. Results Bacterial coinfections were present in 216 of the 351 cases. One hundred and thirty of these cases were evaluated as nosocomial infections. On the third day the Sequential Organ Failure Assessment Score, usage of invasive mechanical ventilation and presence of septic shock were significantly higher in the coinfected group. The neutrophil/lymphocyte ratio, polymorphonuclear leukocyte count, procalcitonin, ferritin, and blood urea nitrogen values were significantly higher in the coinfection group. White blood cells (WBC) (OR: 1.075, 95% CI 1.032–1.121, p  = 0.001) and ICU hospitalization day (OR: 1.114, 95% CI 1.063–1.167, p  < 0.001) were found to be independent risk factors for coinfection in the multivariate logistic regression analysis. The rates of hospitalization day on the day of arrival, the 21st day, as well as total mortality ( p  = 0.004), were significantly higher in the coinfected group. Conclusion Bacterial coinfections of COVID-19 patients in the intensive care unit remain a problem. Identifying the infectious agent, classifying colonizations and infections, and using the proper treatment of antibiotics are of great importance in the case management of COVID-19 patients in the intensive care unit.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Analysis / Antibiotics / B cells / Bacterial coinfection / Bacterial infections / Biomedicine / Cardiovascular disease / Catheters / Coinfection - epidemiology / Comorbidity / Coronaviruses / COVID-19 / COVID-19 - epidemiology / Ferritin / Health aspects / Hospitalization / Hospitals / Humans / Infection / Infectious Diseases / Intensive care / Intensive care unit / Intensive Care Units / Internal Medicine / Laboratories / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Microorganisms / Mortality / Nosocomial infections / Oncology / Pneumonia / Prognosis / Regression analysis / Retrospective Studies / Sepsis / Septic shock / Severe acute respiratory syndrome coronavirus 2 / Shock, Septic / Staphylococcus infections / Steroids / Surgery / Tomography / Urea / Urinary tract diseases / Urinary tract infections / Urogenital system / Ventilators