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Genome Tunisia Project: paving the way for precision medicine in North Africa
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Genome Tunisia Project: paving the way for precision medicine in North Africa
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Journal Article
Genome Tunisia Project: paving the way for precision medicine in North Africa
2024
Overview
Background
Key discoveries and innovations in the field of human genetics have led to the foundation of molecular and personalized medicine. Here, we present the
Genome Tunisia Project, a two-phased initiative (2022–2035)
which aims to deliver the reference sequence of the Tunisian Genome and to support the implementation of personalized medicine in Tunisia, a North African country that represents a central hub of population admixture and human migration between African, European, and Asian populations.
The main goal of this initiative is to develop a healthcare system capable of incorporating
omics
data for use in routine medical practice, enabling medical doctors to better prevent, diagnose, and treat patients.
Methods
A multidisciplinary partnership involving Tunisian experts from different institutions has come to discern all requirements that would be of high priority to fulfill the project’s goals. One of the most urgent priorities is to determine the reference sequence of the Tunisian Genome. In addition, extensive situation analysis and revision of the education programs, community awareness, appropriate infrastructure including sequencing platforms and biobanking, as well as ethical and regulatory frameworks, have been undertaken towards building sufficient capacity to integrate personalized medicine into the Tunisian healthcare system.
Results
In the framework of this project, an ecosystem with all engaged stakeholders has been implemented including healthcare providers, clinicians, researchers, pharmacists, bioinformaticians, industry, policymakers, and advocacy groups. This initiative will also help to reinforce research and innovation capacities in the field of genomics and to strengthen discoverability in the health sector.
Conclusions
Genome Tunisia is the first initiative in North Africa that seeks to demonstrate the major impact that can be achieved by Human Genome Projects in low- and middle-income countries to strengthen research and to improve disease management and treatment outcomes, thereby reducing the social and economic burden on healthcare systems. Sharing this experience within the African scientific community is a chance to turn a major challenge into an opportunity for dissemination and outreach. Additional efforts are now being made to advance personalized medicine in patient care by educating consumers and providers, accelerating research and innovation, and supporting necessary changes in policy and regulation.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
