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Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
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Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
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Journal Article
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
2021
Overview
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer’s disease (AD)
1
,
2
, but how these loci confer AD risk is unclear. Here, we aimed to identify loci that confer AD risk through their effects on brain protein abundance to provide new insights into AD pathogenesis. To that end, we integrated AD GWAS results with human brain proteomes to perform a proteome-wide association study (PWAS) of AD, followed by Mendelian randomization and colocalization analysis. We identified 11 genes that are consistent with being causal in AD, acting via their
cis
-regulated brain protein abundance. Nine replicated in a confirmation PWAS and eight represent new AD risk genes not identified before by AD GWAS. Furthermore, we demonstrated that our results were independent of
APOE e4
. Together, our findings provide new insights into AD pathogenesis and promising targets for further mechanistic and therapeutic studies.
Integrating human brain proteomes with genome-wide association data followed by Mendelian randomization identifies 11 genes with potentially causal roles in Alzheimer’s disease pathogenesis.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 631/378
/ 82/80
/ Alzheimer Disease - genetics
/ Alzheimer Disease - metabolism
/ Amyotrophic lateral sclerosis
/ Animal Genetics and Genomics
/ Apolipoproteins E - genetics
/ Biomedical and Life Sciences
/ Brain
/ Epoxide Hydrolases - genetics
/ Genes
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Humans
/ Letter
/ Loci
/ Parkinson Disease - genetics
/ Polymorphism, Single Nucleotide
/ Proteins
/ Risk
