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Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification

by Cao, Hao , Hua, Huiming , Wang, Chao , Li, Haonan , Li, Dahong , Hou, Yonglian , Wang, Siyuan

in Alkaloids / Angiogenesis / anti-tumor / Antibiotics / Anticancer properties / Antineoplastic Agents - pharmacology / Apoptosis / Autophagy / Biological activity / Cancer therapies / Cell cycle / Cell growth / Cyclin-dependent kinases / Cytotoxicity / DNA / Drug resistance / fascaplysin / Health aspects / Indoles - pharmacology / Kinases / Lung cancer / marine alkaloid / medicinal properties / Melanoma / Natural products / Organic compounds / Planar structures / Proteins / Review / Skin cancer / Synthesis / synthetic chemistry / Vascular endothelial growth factor

2023

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Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification

by Cao, Hao , Hua, Huiming , Wang, Chao , Li, Haonan , Li, Dahong , Hou, Yonglian , Wang, Siyuan

2023

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Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification

by Cao, Hao , Hua, Huiming , Wang, Chao , Li, Haonan , Li, Dahong , Hou, Yonglian , Wang, Siyuan

2023

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Journal Article

Marine-Derived Lead Fascaplysin: Pharmacological Activity, Total Synthesis, and Structural Modification

Cao, Hao,

Hua, Huiming,

Wang, Chao,

Li, Haonan,

Li, Dahong,

Hou, Yonglian,

Wang, Siyuan

2023

Overview

Fascaplysin is a planar structure pentacyclic alkaloid isolated from sponges, which can effectively induce the apoptosis of cancer cells. In addition, fascaplysin has diverse biological activities, such as antibacterial, anti-tumor, anti-plasmodium, etc. Unfortunately, the planar structure of fascaplysin can be inserted into DNA and such interaction also limits the further application of fascaplysin, necessitating its structural modification. In this review, the biological activity, total synthesis and structural modification of fascaplysin will be summarized, which will provide useful information for pharmaceutical researchers interested in the exploration of marine alkaloids and for the betterment of fascaplysin in particular.

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Publisher

MDPI AG,MDPI

Subject

/ Anticancer properties

/ Antineoplastic Agents - pharmacology

/ Apoptosis