Asset Details
Do you wish to reserve the book?
The pathophysiology of ‘happy’ hypoxemia in COVID-19
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The pathophysiology of ‘happy’ hypoxemia in COVID-19
Do you wish to request the book?
The pathophysiology of ‘happy’ hypoxemia in COVID-19
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The pathophysiology of ‘happy’ hypoxemia in COVID-19
2020
Overview
The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional signs of respiratory distress (i.e. happy hypoxemia) and rapid deterioration can occur. This particular clinical presentation in COVID-19 patients contrasts with the experience of physicians usually treating critically ill patients in respiratory failure and ensuring timely referral to the intensive care unit can, therefore, be challenging. A thorough understanding of the pathophysiological determinants of respiratory drive and hypoxemia may promote a more complete comprehension of a patient’s clinical presentation and management. Preserved oxygen saturation despite low partial pressure of oxygen in arterial blood samples occur, due to leftward shift of the oxyhemoglobin dissociation curve induced by hypoxemia-driven hyperventilation as well as possible direct viral interactions with hemoglobin. Ventilation-perfusion mismatch, ranging from shunts to alveolar dead space ventilation, is the central hallmark and offers various therapeutic targets.
Publisher
BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC
Subject
/ Anoxemia
/ Bypasses
/ Complications and side effects
/ Coronavirus Infections - complications
/ Coronavirus Infections - epidemiology
/ COVID-19
/ Dyspnea
/ Humans
/ Medicine
/ Oxygen Consumption - physiology
/ Patients
/ Pneumology/Respiratory System
/ Pneumonia, Viral - complications
/ Pneumonia, Viral - epidemiology
/ Respiratory Insufficiency - complications
/ Respiratory Insufficiency - metabolism
/ Respiratory Insufficiency - physiopathology
/ Review
/ Severe acute respiratory syndrome coronavirus 2
/ Shunts
