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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

by Carvajal-Carmona, Luis , Rowan, Andrew , Lubbe, Steven , Campbell, Harry , Webb, Emily , Gray, Richard , Houlston, Richard , Peto, Julian , Spain, Sarah , Barclay, Ella , Qureshi, Mobshra , Pittman, Alan , Dunlop, Malcolm , Tenesa, Albert , Gorman, Maggie , Papaemmanuil, Elli , Tomlinson, Ian , Cazier, Jean-Baptiste , Sullivan, Kate , Heinimann, Karl , Jaeger, Emma , Wood, Wendy , Howarth, Kimberley , Walther, Axel , Martin, Lynn , Penegar, Steven , Farrington, Susan , Thomas, Huw , Domingo, Enric , Vijayakrishnan, Jayaram , Kerr, David , Broderick, Peter , Kemp, Zoe , Chandler, Ian

in Adenoma - genetics / Agriculture / Animal Genetics and Genomics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Cell Line, Tumor / Cells, Cultured / Chromosomes / Chromosomes, Human, Pair 15 / Colorectal cancer / Colorectal carcinoma / Colorectal Neoplasms - genetics / Diagnosis / Fundamental and applied biological sciences. Psychology / Gastroenterology. Liver. Pancreas. Abdomen / Gene Function / Genetic aspects / Genetic Predisposition to Disease / Genetic variance / Genetic variation / Genetics of eukaryotes. Biological and molecular evolution / Health risks / Human Genetics / Humans / Jews - genetics / Medical sciences / Physiological aspects / Polymorphism, Single Nucleotide / Population genetics / Risk factors / Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / Tumors

2008

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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

2008

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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

2008

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Journal Article

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

Carvajal-Carmona, Luis,

Rowan, Andrew,

Lubbe, Steven,

Campbell, Harry,

Webb, Emily,

Gray, Richard,

Houlston, Richard,

Peto, Julian,

Spain, Sarah,

Barclay, Ella,

Qureshi, Mobshra,

Pittman, Alan,

Dunlop, Malcolm,

Tenesa, Albert,

Gorman, Maggie,

Papaemmanuil, Elli,

Tomlinson, Ian,

Cazier, Jean-Baptiste,

Sullivan, Kate,

Heinimann, Karl,

Jaeger, Emma,

Wood, Wendy,

Howarth, Kimberley,

Walther, Axel,

Martin, Lynn,

Penegar, Steven,

Farrington, Susan,

Thomas, Huw,

Domingo, Enric,

Vijayakrishnan, Jayaram,

Kerr, David,

Broderick, Peter,

Kemp, Zoe,

Chandler, Ian

2008

Overview

We mapped a high-penetrance gene ( CRAC1 ; also known as HMPS ) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1 ), GREM1 and FMN1 . We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10 −14 ).

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Adenoma - genetics

/ Agriculture

/ Animal Genetics and Genomics

/ Biological and medical sciences

/ Biomedical and Life Sciences

/ Biomedicine

/ brief-communication